I don’t have an observatory, but I have used both these techniques for Remote Video Astronomy to control my mount from inside my house. Now that I am using USB cameras and have a USB cable already running from my laptop inside to the camera outside, I have decided to go back to controlling my mount through the single USB cable out to the telescope. My recent cameras use USB3 cables, so I first tried a USB3 powered hub at the telescope and plugged my DS26cTEC cable into it along with my USB-to-serial adapter that runs to my Celestron hand controller. I was able to use a single powered USB3 extension cable from my laptop inside to the USB3 hub at the telescope and successfully control both the camera and the mount.
However, when I tried a longer powered USB3 active extension cable I started getting a message about too many USB hubs. I was trying to figure out how many I had in my cabling and remembered something about a built in USB2 hub in the DS26cTEC! Then I realized I didn’t need a separate powered USB hub at the telescope. I went back to running my single USB3 extension cable from my laptop directly to the DS26cTEC USB3 cable at the telescope and used one of the two USB2 ports on the back of the camera to connect to the Celestron hand controller (using my USB-to-serial adapter).
Here is a picture of the cable connections to the back of my DS26cTEC. The USB3 cable goes to the USB3 active extension cable to the laptop inside. The USB2 cable goes from the back of the camera to a USB- to-serial adapter which is connected to the telescope hand controller. The other cable is power for the TEC cooling (and the USB2 hub built into the camera).
Here is how I now use just a single cable for Remote Video Astronomy from inside my home (or motorhome). I will probably add a focus motor to my telescope and plug it into the other USB2 port on the back of the camera to make it easy to adjust the focus.
I successfully used Stellarium with ASCOM on my Laptop inside to select and slew to targets, make fine adjustments to center the target, etc. See my 12/20/2020 blog post “DS26cTEC focusing and centering aids” for focusing and centering examples.